This optical biopsy technology enables real-time intraoperative imaging with spatial resolution comparable to histology. In the clinical arena, we pioneered the urological applications of confocal endomicroscopy for bladder cancer (Sonn 2009), upper tract urothelial carcinoma (Bui 2015) and prostate cancer (Lopez 2015). In animal models, we investigated the biodistribution and systemic toxicity of nanoparticle-labeled anti-CD47 (Pan 2017) and demonstrated that CD47-mediated near-infrared photoimmunotherapy, a novel form of targeted phototherapy, led to enhanced tumor destruction and prolonged survival (Kiss 2019). We identified and validated CD47 as a promising cancer imaging target and proposed a strategy for intravesical administration of imaging agents based on therapeutic antibodies (Pan 2014). We have investigated CD47, an innate immune checkpoint, as a bladder cancer imaging and therapeutic target. fluorescence, endomicroscopy, molecular imaging, computer vision, and artificial intelligence) to improve bladder tumor detection and resection. Multimodal optical imaging of bladder cancer A major focus of my lab is to develop enhanced endoscopic imaging technologies (e.g. He has been an invited speaker to numerous international meetings including the Gordon Research Conferences, IEEE-NANOMED, IEEE-NEMS, SPIE, Society of Urologic Oncology, Endourology Society, American Urological Association, and European Association of Urology.ġ. He has authored over 150 manuscripts and served as the editor of the textbook Advances in Image-Guided Urologic Surgery.
He has served as the principal investigator on several R01 grants from the National Institutes of Health and Merit Review Awards from the Department of Veterans Affairs, as well as a standing member of the NIH Instrument Systems Development study section. Liao leads a multidisciplinary laboratory that focuses on development of optical imaging technologies for cancer surgery and molecular diagnostics for urological cancer and infections. Liao is a member of the Bio-X, Stanford Cancer Institute, Center for Artificial Intelligence in Medicine & Imaging, and Institute for Immunity, Transplantation, and Infection.
He completed his urology residency and fellowship in endourology and minimally invasive surgery at UCLA. Liao graduated magna cum laude with highest honors from Harvard University and received his medical degree from Stanford. Liao is a board-certified urologist and maintains an active clinical practice focusing on patients with urological cancer and kidney stone disease at VA Palo Alto Health Care System, where he previously served as the Chief of Urology for 15 years. Joseph Liao is Professor and Vice Chair for Academic Affairs in the Department of Urology at Stanford University School of Medicine. Vice Provost for Undergraduate Education.Office of Vice President for Business Affairs and Chief Financial Officer.Office of VP for University Human Resources.Stanford Woods Institute for the Environment.Stanford Institute for Economic Policy Research (SIEPR).Institute for Stem Cell Biology and Regenerative Medicine.Institute for Human-Centered Artificial Intelligence (HAI).Institute for Computational and Mathematical Engineering (ICME).Freeman Spogli Institute for International Studies.Stanford Doerr School of Sustainability.
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